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Inhibiting glycolysis through hexokinase knockdown in preclinical models acutely attenuated microglial activation and proinflammatory cytokine release after ischemic injury [65]

Standard Dosing: 250-500 mcg Per Day The clinical trial tested doses up to 500 mcg daily with no dose-limiting toxicities

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SLC7A11 is a transmembrane protein with 12 transmembrane domains, with both its N- and C-termini located intracellularly ( Figure 2 )